Very little research has been done in El Guache National Park.
 
Only one preliminary characterization that includes the flower structure and composition of the park's vegetation has been done (Núñez 1990).

There is hardly any data about the fauna residing inside the park.  Lists of land and aquatic vertebrates must be developed.

Although there is no evidence of field sightings of spectacled bear (Tremarctos ornatus), Goldstein (1993) believes that individuals of the species make occasional visits to the park, per reports of local inhabitants who have described how the species is hunted and tell stories of how the bear has ravaged their cattle.  Lic. Shaenandhoa García is leading a project whose objectives are to include an evaluation of the distribution, habitat selection, and landscape use by spectacled bear in the parks of the Portuguesa Range.  Click here for a description of the project.  

In 1994, Rivera (1994) did an evaluation of the biotic integrity of the Guache River, using fish as indicators.  The study does not determine where in the river the samples were collected, so it is not clear if the study covered areas outside the park.

Beginning in 2001, with support from WWF-USA, FUDENA began a project for the legal protection of an ecological corridor between the national parks of the Portuguesa Range (Yacambú, Terepaima, Dinira, El Guache, and Guaramacal).  As part of the project, students from the Simón Bolívar University carried out an exercise using the environmental impact evaluation methodology to determine the positive or negative potential impacts of the link between El Guache and Yacambú National Parks.

Fundación Tierra Viva is currently developing the project "Sustainable Development of the Ospino Municipality," that strives to develop an integrated model for the sustainable development of the highest areas of the municipality.  The project will also try to educate producers that grow coffee inside the park, to promulgate environmentally friendly methods among them.

During the last two years, the park superintendent has organized a bicycle circuit to promote the park among the inhabitants of the States of Lara and Portuguesa.  The bikers ride through approximately 100 km of dirt roads between Yacambú and El Guache parks. The Ospino City Hall in Portuguesa and the Andrés Eloy Blanco City Hall in Lara support this activity.

The Economic and Environment Development Directorate of the Ospino municipality and the Environmental Association of Ospino support and collaborate with the national park's educational activities.