Calipuy National Reserve covers an area of 64,000 ha and features a variety of habitats typical of Peru's middle Andes, between 800-3,900 meters. The soil in the reserve is residual, with rolling terrain. The area is home to a large guanaco population. Calipuy National Sanctuary covers an area of 4,500 ha between 3,450-4,300 meters. The area features plant life typical of Peru's high Andean reaches. The sanctuary includes a large and dense population of Puya Raimondi.
In general, there is little available information on the biodiversity of these protected natural areas, and further research is needed. The most significant species include the Puya Raimondi, which prompted the creation of Calipuy National Sanctuary in the first place, and the guanaco (Lama guanicoe), which prompted the creation of Calipuy National Reserve. There are also populations of puma (Felis concolor), spectacled bear (Tremarctos ornatus), and condor (Vultur gryphus), among others.
Both protected natural areas, particularly Calipuy National Sanctuary, face serious threats that require urgent solutions. ParksWatch-Peru classifies both areas as critically threatened. The main threats to Calipuy National Reserve include poaching, livestock herding, firewood extraction, and lack of vigilance and control. Threats to Calipuy National Sanctuary include human encroachment, cattle ranching, burning and destruction Puya Raimondi and lack of vigilance and control.